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August 15, 2025Open Access

Supplementary Figure 6 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition

Gilbert Z. Murimwa N. Williams Dina Alzhanova Amir Mohammadi Jill M. Westcott Francisca Beato Ruifan Dai Luis Nivelo Francesca Rossi Henry K. Fleming Alexandra F. Tassielli Zeynep Yazgan Jason E. Toombs Jason B. Fleming Aatur D. Singhi Cecilia G. Ethun Huocong Huang Rolf A. Brekken

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Key Points

Inhibition of TGFβ reduces IL-6 expression, leading to decreased STAT3 activation in pancreatic cancer.
Significant decline in IL-6 and STAT3 was observed upon TGFβ inhibition, indicating a potential therapeutic pathway.
The study focused on PDAC, showcasing the interplay of SMAD4 deficiency and TGFβ signaling.
Discovering the effects on IL-6 and STAT3 highlights a critical component of pancreatic cancer progression.

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Implication

Inhibition of TGFβ reduces IL-6 levels and STAT3 activation in PDAC, suggesting altered cancer progression dynamics.

Abstract

Inhibition of TGFb reduces IL-6 expression and STAT3 activation in PDAC

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Cite This Study

Murimwa et al. (2025) studied this question.

synapsesocial.com/papers/68af56faad7bf08b1eadd16b https://doi.org/10.1158/0008-5472.29918593

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Supplementary Figure 7 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
2Supplementary Figure 5 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
3Supplementary Figure 2 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
4Supplementary Figure 1 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025
5Supplementary Figure 4 from SMAD4 Deficiency Promotes Pancreatic Cancer Progression and Confers Susceptibility to TGFβ Inhibition2025