What question did this study set out to answer?

To evaluate the global research landscape on poloxamer and hyaluronic acid for nerve root fibrosis prevention.

April 8, 2026Open Access

effect of poloxamer and hyaluronic acid administration in nerve root fibrosis and adhesion prevention following laminectomy: a novel bibliometric analysis

RERieva ErmawanSebelas Maret University GIGian IvanderSebelas Maret University JSJuanda SetiajayaSebelas Maret University

Key Points

To evaluate the global research landscape on poloxamer and hyaluronic acid for nerve root fibrosis prevention.
Conducted a bibliometric analysis using the Web of Science Core Collection.
Evaluated publications on poloxamer and hyaluronic acid from 2000 to 2024.
Performed citation analysis, co-authorship networks, and keyword co-occurrence mapping.
Identified 42 relevant studies in the analysis.
Noted a significant increase in publications, especially in 2016.
Turkey, China, and Taiwan were the top contributing countries.

Abstract

Background Nerve root fibrosis (NRF) is a common postoperative complication following spinal decompression procedures and is associated with persistent pain and functional impairment. Although poloxamer and hyaluronic acid (HA) have been investigated as anti-adhesive agents, the global research landscape in this field has not been systematically evaluated. Methods A bibliometric analysis was conducted using the Web of Science Core Collection to evaluate publications on poloxamer and HA for NRF prevention from 2000 to 2024. Citation analysis, co-authorship networks, and keyword co-occurrence including citation trends, co-authorship networks, and keyword co-occurrence mapping analysis were performed. Results The final investigation comprised 42 relevant studies. The annually publishing trend indicated a considerable growth in research interest, with the largest number of publications in 2016(7 articles). Between 2020 and 2024, approximately 35% (15/42) of the total studies were published, indicating a growing focus on this field. The top contributing countries were Turkey (16 articles, 37.1%), China (13 articles, 30.2%), and Taiwan (7 articles, 16.3%). Citation analysis found that the most referenced journal was the Journal of Neurosurgery: Spine numbering 87 citations, followed by European Spine Journal (58 citations) and Neurosurgery Journal (55 citations). Co-citation analysis highlighted Mei-Hsiu C (70 citations) and Yu S (67 citations) as key researchers in this domain. Keyword mapping indicated that major research themes included “epidural fibrosis” (32 occurrences), “laminectomy” (24 occurrences), and “adhesion” (10 occurrences). Conclusion Research on poloxamer and HA for NRF prevention has increased steadily, with emerging emphasis on inflammation modulation and biomaterial optimization. These findings provide a comprehensive overview of current trends and future research directions.

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