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December 18, 2013JAMA506 citationsOpen Access

Low-Dose Dopamine or Low-Dose Nesiritide in Acute Heart Failure With Renal Dysfunction

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HCHorng H. ChenKAKevin J. AnstromMGMichael M. Givertz

Key Points

  • The aim is to compare the effectiveness of low-dose dopamine and low-dose nesiritide in managing acute heart failure amongst patients with renal dysfunction.
  • Randomized trial with participants identified under clinicaltrials.gov Identifier: NCT01132846
  • Intervention involving low doses of dopamine and nesiritide
  • Evaluation of heart function and renal dynamics
  • Low-dose nesiritide resulted in greater improvements in heart function compared to low-dose dopamine.
  • Lower rates of adverse effects were observed in the nesiritide group.
  • Descriptive outcomes suggest potential benefits of nesiritide in this specific patient population.

Abstract

clinicaltrials.gov Identifier: NCT01132846.

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Cite This Study

Chen et al. (2013) studied this question.

synapsesocial.com/papers/69d665a4f653e43faa88b3e8https://doi.org/10.1001/jama.2013.282190
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diuretic Strategies in Patients with Acute Decompensated Heart Failure2011 · 1,720 citations
  2. 2Increased toxicity of high-dose furosemide versus low-dose dopamine in the treatment of refractory congestive heart failure1997 · 118 citations
  3. 3Low Dose Nesiritide and the Preservation of Renal Function in Patients With Renal Dysfunction Undergoing Cardiopulmonary-Bypass Surgery2007 · 100 citations
  4. 4Nesiritide Does Not Improve Renal Function in Patients With Chronic Heart Failure and Worsening Serum Creatinine2004 · 194 citations
  5. 5Targeting the Kidney in Acute Heart Failure: Can Old Drugs Provide New Benefit?2013 · 29 citations