Key result
Elevated platelet-to-haemoglobin ratio predicts post-anterior MI apical thrombus with ~69% sensitivity.
Why the study?
Apical thrombus is a severe complication in myocardial infarction increasing thromboembolic risk, and platelet-to-haemoglobin ratio is a novel predictor of cardiovascular outcomes whose association with apical thrombus was unexplored.
Does the platelet-to-haemoglobin ratio predict the development of left ventricular apical thrombus in patients with anterior myocardial infarction?
Case-Control (n=690)
Does the platelet-to-haemoglobin ratio predict the development of left ventricular apical thrombus in patients with anterior myocardial infarction?
Answers are grounded in this paper and cite their sources.
The platelet-to-haemoglobin ratio is a simple, accessible biomarker that can help predict the development of left ventricular apical thrombus in patients with anterior myocardial infarction.
OBJECTIVE: Apical thrombus (AT) is a severe complication in myocardial infarction (MI), increasing the risk of thromboembolic events. Platelet-to-haemoglobin ratio (PHR) is a novel, inexpensive predictor of cardiovascular outcomes. This study explores the association between PHR and AT in MI patients. MATERIALS & METHODS: This retrospective study included 690 anterior MI patients (314 patients with AT and 376 patients without AT as a control group). Blood samples were analysed to calculate PHR, and echocardiographic evaluations identified AT. Logistic regression and ROC analysis determined independent predictors and the optimal PHR cut-off value for AT. Multivariate analysis identified PHR, proximal LAD lesions, and lower LVEF as independent predictors. The PHR cut-off of 1.88 showed 69.3% sensitivity and 68.4% specificity. CONCLUSION: PHR is a simple, accessible marker for predicting AT in MI patients. Its use may improve early risk stratification and clinical outcomes.
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Algül et al. (2025) conducted a case-control in Anterior myocardial infarction (n=690). Platelet-to-haemoglobin ratio (PHR) vs. Patients without apical thrombus was evaluated on Left ventricular apical thrombus (p=<0.001). A platelet-to-haemoglobin ratio cut-off of 1.88 predicted left ventricular apical thrombus in anterior MI patients with 69.3% sensitivity and 68.4% specificity.
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