Key result
Water drinking raises sympathetic activity and blood pressure in autonomic failure and older adults.
Why the study?
The pressor effect of oral water drinking is an important yet unrecognized confounding factor in clinical studies of pressor agents and antihypertensive medications.
Does oral water drinking increase blood pressure and sympathetic activity in autonomic failure patients and older normal subjects?
Does oral water drinking increase blood pressure and sympathetic activity in autonomic failure patients and older normal subjects?
Oral water drinking acutely raises blood pressure, serving as a potential treatment for orthostatic hypotension and a confounding factor in hypertension trials.
May support water as nonpharmacologic option for orthostatic hypotension; leaves open confirmation versus confounding in hypertension trials.
Water drinking significantly and rapidly raises sympathetic activity. Indeed, it raises plasma norepinephrine as much as such classic sympathetic stimuli as caffeine and nicotine. This effect profoundly increases blood pressure in autonomic failure patients, and this effect can be exploited to improve symptoms due to orthostatic hypotension. Water drinking also acutely raises blood pressure in older normal subjects. The pressor effect of oral water is an important yet unrecognized confounding factor in clinical studies of pressor agents and antihypertensive medications.
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Jordan et al. (2000) conducted a review in Autonomic failure and orthostatic hypotension. Water drinking was evaluated. Water drinking significantly raises sympathetic activity and blood pressure in autonomic failure patients and older normal subjects, acting as a potential confounder in clinical studies.
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