Why the study?
Does TSAT ≤19.8% or serum iron ≤13 µmol/L accurately identify iron deficiency and predict mortality in heart failure patients compared to bone marrow staining?
Does TSAT ≤19.8% or serum iron ≤13 µmol/L accurately identify iron deficiency and predict mortality in heart failure patients compared to bone marrow staining?
TSAT <20% is validated as the best marker for iron deficiency in heart failure, whereas the diagnostic value of ferritin is questioned.
Supports TSAT <20% or serum iron for iron deficiency assessment in HF; extends validation but leaves open prospective trials.
A TSAT ≤19.8% or a serum iron ≤13 µmol/L shows the best performance in selecting patients with ID and identifies HF patients at the highest risk of death. Our findings validate the currently used TSAT cutoff of <20% for the identification of ID in HF patients, but question the diagnostic value of ferritin.
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Beverborg et al. (2018) studied this question.
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