Narrative review evaluates oxidant mechanisms in renal disease, indicating that targeting reactive species generation offers better therapeutic potential than past antioxidants.
Despite the limited success associated with the application of antioxidants for treatment of kidney injury/disease thus far, preventing the generation and accumulation of ROS and RNS provides an ideal target for potential therapeutic treatments. The review discusses the shortcomings of antioxidant treatments previously used and the potential promise of new ones. Antioxid. Redox Signal. 25, 119-146.
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Ratliff et al. (2016) studied this question.
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