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September 14, 2022European Heart Journal - Cardiovascular Pharmacotherapy49 citations

Safety and efficacy of very low LDL-cholesterol intensive lowering: a meta-analysis and meta-regression of randomized trials

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GPGiuseppe PattiESEnrico Guido SpinoniLGLeonardo Grisafi

Structured PICO

Do intensive lipid-lowering treatments achieving very low LDL-C levels reduce cardiovascular events without increasing adverse events?

P
Population
Patients in randomized trials
I
Intervention
Intensive lipid-lowering treatments achieving very low LDL-C levels
O
Outcome
Adverse events and cardiovascular eventshard clinical

Achieving very low LDL-C levels with intensive lipid-lowering therapy is safe and continues to reduce cardiovascular events.

Abstract

This meta-analysis indicates that very low LDL-C levels on intensive lipid-lowering treatments are not associated with any adverse event and maintain a persistent reduction of cardiovascular events.

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Cite This Study

Patti et al. (2022) studied this question.

synapsesocial.com/papers/69d69c65a70b37cec732f98ehttps://doi.org/10.1093/ehjcvp/pvac049
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