January 1, 2007Annals of Neurology
Paraneoplastic anti– N ‐methyl‐ D ‐aspartate receptor encephalitis associated with ovarian teratoma
Authors
Discussion
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Implication
Clinical study demonstrates antibodies to NMDAR subunits cause reversible encephalitis, suggesting a diagnostic model for autoimmune cognitive disorders.
Key Points
- To identify autoantibodies targeting specific NMDA receptor subunits in patients with severe encephalitis and establish a diagnostic framework.
- Screened patient sera and cerebrospinal fluid for autoantibodies reactive against NR2A- and NR2B-containing NMDAR heteromers.
- Assessed clinical outcomes and therapeutic responsiveness in patients with tumor-associated encephalitis.
- Antibodies targeting NR2B- and NR2A-containing NMDAR heteromers strongly associate with severe, paraneoplastic encephalitis.
- Identified disease presentations demonstrate high responsiveness to immunotherapy and tumor resection despite severe initial symptoms.
Cite This Study
Dalmau et al. (2007) studied this question.