Repeated Binge Drinking Increases Perineuronal Nets in the Insular Cortex

This is the authors' abstract. We don't add key points for this paper.

Our results provide the first evidence that insular PNs increase after long-term binge drinking. The insula mediates compulsive alcohol use. As PNs influence neuronal firing and plasticity, increased PNs in the insula after multiple binge cycles may contribute to restricted neuronal plasticity and lead to the development of compulsive alcohol use.