Why the study?
Does chronic kidney disease affect the prevalence and survival outcomes of left-sided valvular heart disease (AS and MR)?
Does chronic kidney disease affect the prevalence and survival outcomes of left-sided valvular heart disease (AS and MR)?
Chronic kidney disease is associated with a higher prevalence of left-sided valvular heart disease and synergistically worsens mortality as valve disease severity increases.
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CKD patients warrant closer valvular monitoring; extends observational data but leaves causal effects and interventions open.
Prevalence of at least mild AS and MR is substantially higher and is associated with significantly lower survival among patients with versus without CKD. There is significant interaction among CKD, AS/MR severity, and mortality, with increasingly worse outcomes for CKD patients with increasing AS/MR severity.
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Samad et al. (2017) studied this question.
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