What question did this study set out to answer?

Identify the specific genetic mechanism underlying DDT resistance conferred by the DDT-R locus and determine how resistant alleles spread in Drosophila melanogaster populations.

September 27, 2002Science

A Single P450 Allele Associated with Insecticide Resistance in Drosophila

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Authors

PDPhillip J. DabornBiotechnology Institute JYJanet L. YenBoston Children's Hospital MBMichael BogwitzPeter MacCallum Cancer Centre

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Implication

Genetic analysis reveals that overtranscription of a single Cyp6g1 allele confers DDT resistance in Drosophila melanogaster, indicating rapid global spread driven by a transposable element.

Key Points

Identify the specific genetic mechanism underlying DDT resistance conferred by the DDT-R locus and determine how resistant alleles spread in Drosophila melanogaster populations.
Conducted microarray expression profiling across all cytochrome P450 genes in Drosophila melanogaster.
Performed transgenic functional assays of Cyp6g1 to evaluate its role in conferring insecticide resistance.
Screened global Drosophila melanogaster populations to characterize genetic variation at the Cyp6g1 locus.
DDT resistance was associated specifically with the overtranscription of a single cytochrome P450 gene, Cyp6g1.
Transgenic expression demonstrated that overtranscription of Cyp6g1 alone is both necessary and sufficient for conferring resistance.
Resistance across global populations traced to a single widespread allele characterized by the insertion of an Accord transposable element into the 5' end of Cyp6g1.

Cite This Study

Daborn et al. (2002) studied this question.

synapsesocial.com/papers/69d6bb23e328128020aa81fa https://doi.org/10.1126/science.1074170

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Implication

Genetic analysis reveals that overtranscription of a single Cyp6g1 allele confers DDT resistance in Drosophila melanogaster, indicating rapid global spread driven by a transposable element.

A Single P450 Allele Associated with Insecticide Resistance in Drosophila

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Implication

Key Points

Cite This Study

A Single P450 Allele Associated with Insecticide Resistance in Drosophila

Discussion

Member takes

Implication

Key Points

Cite This Study

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