Does early pharmacologic VTE prophylaxis reduce thromboembolic complications in patients who underwent urgent neurosurgical interventions for traumatic brain injury?
Early VTE prophylaxis after urgent TBI neurosurgery reduces thromboembolism but increases the risk of repeated neurosurgery if initiated within the first 3 days.
In this cohort study of patients who underwent urgent neurosurgical interventions for TBI, early pharmacologic VTE prophylaxis was associated with reduced risk of thromboembolism. However, earlier initiation of prophylaxis was associated with increased risk of repeated neurosurgery. These findings suggest that although timely initiation of prophylaxis should be prioritized, caution should be used particularly during the first 3 days after the index procedure, when this risk appears to be highest.
Byrne et al. (Wed,) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: