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March 26, 2009ChemMedChem

Asborin: The Carbaborane Analogue of Aspirin

M. Scholz Kerstin Bensdorf Ronald Gust Evamarie Hey‐Hawkins

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Abstract

Asborin , the carbaborane analogue of aspirin, was obtained by a high‐yield synthetic procedure and proved to be an active cyclooxygenase (COX) inhibitor (H: white, B: beige, C: gray, O: blue). magnified image

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Scholz et al. (2009) studied this question.

synapsesocial.com/papers/69d6c34a8dca315383ed8dd2 https://doi.org/10.1002/cmdc.200900072

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Structural requirements for the neuroprotective effects of aspirin analogues against N-methyl-D-aspartate and zinc ion neurotoxicityOriginal Research · 2002 · 8 citations
2Novel Boron-Containing, Nonclassical Antifolates: Synthesis and Preliminary Biological and Structural EvaluationIn Vitro Study · 2007 · 78 citations
3Synthesis and evaluation of transthyretin amyloidosis inhibitors containing carborane pharmacophoresOriginal Research · 2007 · 119 citations
4Acetylation of human prostaglandin endoperoxide synthase-2 (cyclooxygenase-2) by aspirin.Original Research · 1994 · 371 citations
5Completion and refinement of crystal structures with<i>SIR</i>92Original Research · 1993 · 5,144 citations

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