Distinct clusters of risk factors determine the risk for developing HFpEF versus HFrEF, which could inform targeted prevention strategies.
Although multiple risk factors preceded overall HF, distinct clusters of risk factors determine risk for new-onset HFPEF versus HFREF. This knowledge may enable the design of clinical trials of targeted prevention and the introduction of therapeutic strategies for prevention of HF and its 2 major subtypes.
Ho et al. (2012) studied this question.