Distinct clusters of risk factors determine the risk for developing HFpEF versus HFrEF, which could inform targeted prevention strategies.
Supports distinct prevention targets for HFpEF versus HFrEF; hypothesis-generating and requires prospective validation.
Although multiple risk factors preceded overall HF, distinct clusters of risk factors determine risk for new-onset HFPEF versus HFREF. This knowledge may enable the design of clinical trials of targeted prevention and the introduction of therapeutic strategies for prevention of HF and its 2 major subtypes.
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Ho et al. (2012) studied this question.
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