What question did this study set out to answer?

To identify the signaling pathways through which caloric restriction and its mimetics stimulate autophagy in cortical neurons.

March 14, 2021AgingOpen Access

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

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Authors

MFMarisa Ferreira‐MarquesUniversity of Coimbra ACAndré CarvalhoUniversidade de São Paulo CCCláudia CavadasUniversity of Coimbra

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Implication

Laboratory study reveals caloric restriction and mimetics trigger autophagy via kinase modulation in rat cortical neurons, suggesting novel targets for neurodegenerative disorders.

Key Points

To identify the signaling pathways through which caloric restriction and its mimetics stimulate autophagy in cortical neurons.
Examined rat cortical neurons exposed to caloric restriction or caloric restriction mimetics, specifically neuropeptide Y and ghrelin.
Analyzed the involvement and modulation of downstream kinase cascades, focusing on the PI3K/AKT/MTOR and ERK1/2-MAPK pathways during autophagy stimulation.
Caloric restriction, neuropeptide Y, and ghrelin stimulated neuronal autophagy through the inhibition of the PI3K/AKT/MTOR signaling axis.
Activation of the ERK1/2-MAPK pathway was additionally identified as an essential mechanism driving the autophagy stimulation triggered by these interventions.

Cite This Study

Ferreira‐Marques et al. (2021) studied this question.

synapsesocial.com/papers/69d6ca54f174babf6cab38cd https://doi.org/10.18632/aging.202805

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Implication

Laboratory study reveals caloric restriction and mimetics trigger autophagy via kinase modulation in rat cortical neurons, suggesting novel targets for neurodegenerative disorders.

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

Discussion

Member takes

Implication

Key Points

Cite This Study

PI3K/AKT/MTOR and ERK1/2-MAPK signaling pathways are involved in autophagy stimulation induced by caloric restriction or caloric restriction mimetics in cortical neurons

Discussion

Member takes

Implication

Key Points

Cite This Study

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