What question did this study set out to answer?

To examine how tumor cells functionally reprogram stromal and immune cell components within the surrounding microenvironment to drive tumor survival, growth, and metastasis.

July 26, 2019Cancer ResearchOpen Access

The Tumor Microenvironment Innately Modulates Cancer Progression

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To examine how tumor cells functionally reprogram stromal and immune cell components within the surrounding microenvironment to drive tumor survival, growth, and metastasis.
Synthesized molecular evidence on cancer-directed stromal remodeling mediated by cytokines, chemokines, and secreted signaling factors.
Characterized functional contributions of innate immune cells (macrophages, neutrophils, dendritic cells, innate lymphoid cells, myeloid-derived suppressor cells, and natural killer cells) and adaptive immune cells (T and B cells) within the tumor stroma.
Cancer cells reprogram surrounding stromal cells through targeted cytokine and chemokine secretion to promote cell survival and local invasion.
Recruitment and functional alteration of both innate and adaptive immune cell populations generate an immunosuppressive niche that accelerates metastatic dissemination.
Therapeutic regimens simultaneously targeting multiple signaling axes between cancer cells and the tumor stroma offer improved clinical efficacy over single-agent strategies.

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Implication

Review reveals stroma-mediated immune reprogramming in cancer patients, highlighting therapeutic opportunities for multi-targeted interventions.

Cite This Study

Hinshaw et al. (2019) studied this question.

synapsesocial.com/papers/69d6cee8e328128020aa85ee https://doi.org/10.1158/0008-5472.can-18-3962

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Implication

Review reveals stroma-mediated immune reprogramming in cancer patients, highlighting therapeutic opportunities for multi-targeted interventions.

The Tumor Microenvironment Innately Modulates Cancer Progression

Key Points

Discussion

Implication

Cite This Study

The Tumor Microenvironment Innately Modulates Cancer Progression

Key Points

Discussion

Implication

Cite This Study

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