In vitro study reveals magnesium suppresses phosphate-induced calcification in vascular smooth muscle cells, indicating a protective mechanism via calciprotein particle inhibition.
Our results demonstrate that crystalline CPP2 mediates Pi-induced calcification in VSMCs. In vitro, Mg2+ delays crystalline CPP2 formation and thereby prevents Pi-induced calcification.
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Braake et al. (2019) studied this question.
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