Identification of a DNMT1-HIF-1α-PDK-mediated epigenetic mitochondrial-metabolic pathway that promotes right ventricular fibrosis in pulmonary arterial hypertension, highlighting a potential therapeutic target.
MCT-RVfib manifest a DNMT1-HIF-1α-PDK-mediated, chamber-specific, metabolic memory that promotes collagen production and RV fibrosis. This epigenetic mitochondrial-metabolic pathway is a potential antifibrotic therapeutic target.
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Tian et al. (2020) studied this question.
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