June 29, 2010Circulation
Survival in Patients With Idiopathic, Familial, and Anorexigen-Associated Pulmonary Arterial Hypertension in the Modern Management Era
Key result
PAH mortality remains high and is linked to male sex, RV dysfunction, and exercise limitation.
Why the study?
Idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension remains a progressive, fatal disease despite modern management.
What factors are associated with mortality in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era?
Population
Patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension
Design
Other
Authors
Discussion
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Member takes
Implication
These associations may aid PAH risk stratification; leaves open whether targeting RV function or exercise alters survival.
Structured PICO
What factors are associated with mortality in patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension in the modern management era?
P
Population
Patients with idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension
O
Outcome
Mortalityhard clinical
Idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension remains a progressive, fatal disease, with mortality driven by male gender, right ventricular hemodynamics, and exercise limitation.
Cite This Study
Humbert et al. (2010) studied this question. Idiopathic, familial, and anorexigen-associated pulmonary arterial hypertension remains fatal, with mortality linked to male gender, right ventricular function, and exercise limitation.