FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

Melina Claussnitzer; Simon N. Dankel; Kyoung-Han Kim; Gerald Quon; Wouter Meuleman; Christine E. Haugen; Viktoria Glunk; Isabel Sousa; Jacqueline L. Beaudry; Vijitha Puviindran; Nezar Abdennur; Jannel Liu; Per‐Arne Svensson; Yi-Hsiang Hsu; Daniel J. Drucker; Gunnar Mellgren; Chi-chung Hui; Hans Hauner; Manolis Kellis

doi:10.1056/nejmoa1502214

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Our results point to a pathway for adipocyte thermogenesis regulation involving ARID5B, rs1421085, IRX3, and IRX5, which, when manipulated, had pronounced pro-obesity and anti-obesity effects. (Funded by the German Research Center for Environmental Health and others.).

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Claussnitzer et al. (2015) studied this question.

synapsesocial.com/papers/69d7092a9f004159b8aa7e9f https://doi.org/10.1056/nejmoa1502214

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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

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FTO Obesity Variant Circuitry and Adipocyte Browning in Humans

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