What question did this study set out to answer?

This review aims to explore the complexity and diverse functions regulated by the extracellular signal-regulated kinase (ERK) cascade.

January 1, 2006Growth Factors

The extracellular signal-regulated kinase: Multiple substrates regulate diverse cellular functions

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Review describes the ERK cascade's involvement in diverse cellular processes through multiple substrates, suggesting complexity.

This review aims to explore the complexity and diverse functions regulated by the extracellular signal-regulated kinase (ERK) cascade.
Described the core phosphorylation chain of the ERK cascade including Raf kinases, MEK1/2, and ERK1/2.
Identified about 160 substrates for ERKs and their functions across cellular processes.
Discussed the localization of substrates in the nucleus, cytosol, and other organelles.
Highlighting the multitude of functions regulated by the ERK pathway, including transcription, mitosis, and apoptosis.
Describing mechanisms of substrates' activation and their roles in various cellular conditions.

Yoon et al. (2006) studied this question.

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