June 1, 1995Journal of Biological ChemistryOpen Access

Cloning and Characterization of a RNase L Inhibitor.

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Population

Reticulocyte extracts and stably transfected HeLa cells

Design

Preclinical

Authors

CBCatherine BisbalCentre National de la Recherche Scientifique CMCamille MartinandInstitut de Génétique Moléculaire de Montpellier MSMichelle SilholInserm

Discussion

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Implication

RLI modulation of RNase L may regulate IFN responses; leaves open its in vivo antiviral role pending further study.

Structured PICO

Population

Reticulocyte extracts and stably transfected HeLa cells

Intervention

Expression and overexpression of RLI (RNase L inhibitor)

Outcome

2-5A binding ability and nuclease activity of endogenous RNase Lsurrogate

The cloning and characterization of RLI identifies it as a novel endoribonuclease inhibitor that antagonizes the 2-5A/RNase L pathway and modulates interferon antiviral activity.

Cite This Study

Bisbal et al. (1995) studied this question.

synapsesocial.com/papers/69d70e8f9f004159b8aa7fbb https://doi.org/10.1074/jbc.270.22.13308

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Cloning and Characterization of a RNase L Inhibitor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Cloning and Characterization of a RNase L Inhibitor.

Discussion

Member takes

Implication

Structured PICO

Cite This Study

Also Consider

Also Consider