GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

Grainne M. O’Kane; Barbara T. Grünwald; Gun-Ho Jang; Mehdi Masoomian; Sarah Picardo; Robert C. Grant; Robert E. Denroche; Amy Zhang; Yifan Wang; Jessica K. Miller; Bernard Lam; Paul M. Krzyzanowski; Ilinca M. Lungu; John M.S. Bartlett; Melanie Peralta; Foram Vyas; Rama Khokha; James Biagi; Dianne Chadwick; Stephanie Ramotar; Shawn Hutchinson; Anna Dodd; Julie M. Wilson; Faiyaz Notta; George Zogopoulos; Steven Gallinger; Jennifer J. Knox; Sandra E. Fischer

doi:10.1158/1078-0432.ccr-19-3724

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Abstract

The basal-like subtype is chemoresistant and can be distinguished from classical PDAC by GATA6 expression.See related commentary by Collisson, p. 4715.

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O’Kane et al. (2020) studied this question.

synapsesocial.com/papers/69d70f295413bc3de5ab3514 https://doi.org/10.1158/1078-0432.ccr-19-3724

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GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

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GATA6 Expression Distinguishes Classical and Basal-like Subtypes in Advanced Pancreatic Cancer

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