December 1, 1987The Journal of ImmunologyOpen Access

Cardiac myosin induces myocarditis in genetically predisposed mice.

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Why the study?

Does immunization with cardiac myosin induce myocarditis in genetically predisposed mice?

Population

Genetically predisposed mice strains (A/J, A.SW/SnJ, A.CA/SnJ, A.BY/SnJ, B10.A/SgSnJ, C57BL/6J, C57BL/10J)

Comparison

Immunization with cardiac myosin vs Immunization with skeletal muscle myosin or…

Design

Preclinical

Authors

NNNikolaus NeuStatistisches Bundesamt NRN. R. RoseUniversity of Alabama at Birmingham KBKirk W. BeiselRutgers, The State University of New Jersey

Discussion

Member takes

Implication

Establishes a murine model of autoimmune myocarditis; leaves open translation to human disease and requires prospective validation.

Structured PICO

Does immunization with cardiac myosin induce myocarditis in genetically predisposed mice?

Population

Genetically predisposed mice strains (A/J, A.SW/SnJ, A.CA/SnJ, A.BY/SnJ, B10.A/SgSnJ, C57BL/6J, C57BL/10J)

Intervention

Immunization with cardiac myosin

Comparator

Immunization with skeletal muscle myosin or complete Freund's adjuvant

Outcome

Development of severe myocarditis and high titers of myosin autoantibodiessurrogate

This study establishes a new animal model for autoimmune heart disease by demonstrating that cardiac myosin induces myocarditis in genetically susceptible mice.

Cite This Study

Neu et al. (1987) studied this question.

synapsesocial.com/papers/69d71b27faf9bc6d3dbef032 https://doi.org/10.4049/jimmunol.139.11.3630

Topics

Myocarditis

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