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January 28, 2015TransplantationOpen Access

Characteristics of Circulating Donor Human Leukocyte Antigen-specific Immunoglobulin G Antibodies Predictive of Acute Antibody-mediated Rejection and Kidney Allograft Failure

Dinesh Kannabhiran J. Jack Lee Joseph E. Schwartz Rex Friedlander Meredith J. Aull Thangamani Muthukumar Sean R. Campbell D. B. A. Epstein Surya V. Seshan Sandip Kapur Vijay K. Sharma Manikkam Suthanthiran Darshana M. Dadhania

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Abstract

Our study suggests that DSA MFI-Sum and HLA class of DSA are characteristics predictive of AMR and graft failure. The elevated risk of graft failure in those with the identified features of DSA is attributable to increased risk of AMR.

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Cite This Study

Kannabhiran et al. (2015) studied this question.

synapsesocial.com/papers/69d72093cd480cb7e5f5097d https://doi.org/10.1097/tp.0000000000000511

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Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

1Significance of the Positive Crossmatch Test in Kidney TransplantationCohort Study · 1969 · 1,511 citations
2Clinical Relevance of Preformed HLA Donor-Specific Antibodies in Kidney TransplantationRetrospective Study · 2008 · 244 citations
3Detection of donor-specific antibodies using HLA-coated microspheres: another tool for kidney transplant risk stratification**Portions of this study were delivered as an oral presentation at the American Transplant Congress, Seattle, WA, 20–25 May 2005.Cohort Study · 2006 · 117 citations
4Organ Procurement and Transplantation Network/United Network for Organ Sharing Histocompatibility Committee Collaborative Study to Evaluate Prediction of Crossmatch Results in Highly Sensitized PatientsOriginal Research · 2009 · 42 citations
5Advanced multiplexed analysis with the FlowMetrixTM systemOriginal Research · 1997 · 650 citations

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