New aspects of N-oxides: Pyrazine, pyridazine, and pyrimidine N-oxides are regioselectively arylated with aryl iodides, bromides, and chlorides in the presence of a palladium catalyst (see scheme). The resulting products can be deoxygenated in high yield or further functionalized by making use of the N-oxide functionality. FG=functional group.
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Leclerc et al. (2006) studied this question.
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