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Observational study reveals low vascular complications in patients with glucokinase mutations despite lifelong mild hyperglycemia, indicating minimal risk from isolated blood sugar elevations.
Despite a median duration of 48.6 years of hyperglycemia, patients with a GCK mutation had low prevalence of microvascular and macrovascular complications. These findings may provide insights into the risks associated with isolated, mild hyperglycemia.
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Steele et al. (2014) studied this question.
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