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June 23, 2006PLoS MedicineOpen Access

Human Monoclonal Antibody Combination against SARS Coronavirus: Synergy and Coverage of Escape Mutants

Jan ter Meulen Edward N. van den Brink Leo L. M. Poon Wilfred E. Marissen Cynthia Sau-Wai Leung Freek Cox Chung Yan Cheung Arjen Q. Bakker Johannes A. Bogaards Els van Deventer Wolfgang Preiser Hans Wilhelm Doerr Vincent Chow John de Kruif Malik Peiris Jaap Goudsmit

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Abstract

The combination of two noncompeting human mAbs CR3014 and CR3022 potentially controls immune escape and extends the breadth of protection. At the same time, synergy between CR3014 and CR3022 may allow for a lower total antibody dose to be administered for passive immune prophylaxis of SARS-CoV infection.

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Meulen et al. (2006) studied this question.

synapsesocial.com/papers/69d72238a98988943d56378a https://doi.org/10.1371/journal.pmed.0030237

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