Transthoracic echocardiography is a reliable, non-invasive tool for characterizing cardiac morphology and function in murine models of cardiac disease.
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Should not change clinical practice; supports echocardiography for efficient phenotyping and screening in murine transgenic models.
These studies provide the first application of transthoracic echocardiography for morphological/functional characterization of the cardiac phenotype in transgenic and surgical murine models, including (1) high reliability for detecting LV chamber dilation and function; (2) reliability (and its limits) for determining abnormal LV wall thickness and LV mass; (3) identification of marked, sometimes asymmetrical, hypertrophy in a transgenic model of hypertrophic cardiomyopathy; and (4) usefulness for transgenic colony screening to identify markedly abnormal phenotypes.
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Tanaka et al. (1996) studied this question.
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