What question did this study set out to answer?

This review aims to summarize the structure, function, and biosynthesis of lasso peptides, along with their engineering potentials.

January 1, 2012

Lasso peptides: structure, function, biosynthesis, and engineering

Key Points

This review aims to summarize the structure, function, and biosynthesis of lasso peptides, along with their engineering potentials.
Review of literature on lasso peptides as of mid-2012.
Discussion on isolation, characterization, and bioinformatics strategies.
Highlighting studies on engineering lasso peptides for enhanced functions.
Detailed account of known lasso peptides and their bioactivities.
Insights into biosynthesis processes and molecular modifications.
Identification of gaps in the current understanding of lasso peptide engineering.

Abstract

Lasso peptides are a class of ribosomally-synthesized and posttranslationally-modified natural products with diverse bioactivities. This review describes the structure and function of all known lasso peptides (as of mid-2012) and covers our current knowledge about the biosynthesis of those molecules. The isolation and characterization of lasso peptides are also covered as are bioinformatics strategies for the discovery of new lasso peptides from genomic sequence data. Several studies on the engineering of new or improved function into lasso peptides are highlighted, and unanswered questions in the field are also described.

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