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November 8, 2013Nucleic Acids Research749 citationsOpen Access

SAbDab: the structural antibody database

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JDJames B. DunbarKKKonrad KrawczykJLJinwoo Leem

Key Points

  • To create a centralized, consistently annotated online database containing all publicly available structural data on antibodies.
  • Aggregated publicly available antibody structures into a unified repository.
  • Annotated entries with experimental data, gene sequences, heavy and light chain pairings, antigen characteristics, and binding affinity measurements.
  • Integrated structural query parameters including complementarity determining region (CDR) loop conformations and variable domain orientations.
  • Launched the publicly accessible SAbDab online platform.
  • Enabled custom dataset querying, inspection of structural features, and batch downloading of individual entries or the entire database.

Abstract

Structural antibody database (SAbDab; http://opig.stats.ox.ac.uk/webapps/sabdab) is an online resource containing all the publicly available antibody structures annotated and presented in a consistent fashion. The data are annotated with several properties including experimental information, gene details, correct heavy and light chain pairings, antigen details and, where available, antibody-antigen binding affinity. The user can select structures, according to these attributes as well as structural properties such as complementarity determining region loop conformation and variable domain orientation. Individual structures, datasets and the complete database can be downloaded.

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Cite This Study

Dunbar et al. (2013) studied this question.

synapsesocial.com/papers/69d724413f906f6a06bef64ahttps://doi.org/10.1093/nar/gkt1043
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