February 1, 2001Arteriosclerosis Thrombosis and Vascular Biology
Low Blood Flow After Angioplasty Augments Mechanisms of Restenosis
Why the study?
Does low blood flow augment mechanisms of restenosis in balloon-injured rat carotid arteries?
Structured PICO
Does low blood flow augment mechanisms of restenosis in balloon-injured rat carotid arteries?
P
Population
Rat carotid arteries subjected to balloon catheter injury
I
Intervention
Low blood flow
C
Comparator
Normal and high blood flow
O
Outcome
Vessel morphometry (luminal area and inward remodeling) at 28 dayssurrogate
Low blood flow after angioplasty promotes restenosis through accentuated inward remodeling and augmented expression of promigratory genes.
Authors
Discussion
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Implication
Highlights potential role of hemodynamics in restenosis; animal data leaves open clinical translation.
Cite This Study
Ward et al. (2001) studied this question.