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August 1, 1976British Journal of Haematology

Proposals for the Classification of the Acute Leukaemias French‐American‐British (FAB) Co‐operative Group

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Authors

JBJohn M. BennettNorthwestern UniversityDCDaniel CatovskyBoston UniversityMDMarie‐Theregse DanielHôpital Saint-Louis

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Implication

Collaborative expert review demonstrates a standardized morphological classification for acute leukaemias across 200 cases, highlighting a reliable framework for clinical trials.

Key Points

  • To establish a uniform classification and nomenclature system for acute leukaemias based on conventional morphological and cytochemical criteria.
  • Seven French, American, and British haematologists evaluated peripheral blood and bone-marrow films from approximately 200 cases of acute leukaemia.
  • Films were evaluated independently and subsequently reviewed collaboratively to reach diagnostic consensus using standard morphological and cytochemical methods.
  • Categorized acute leukaemia into two primary divisions: lymphoblastic leukaemia, subdivided into three distinct morphological groups, and myeloid leukaemia, subdivided into six groups.
  • Characterized related dysmyelopoietic syndromes to aid in differentiating non-leukaemic preleukaemic states from acute myeloid leukaemia, accompanied by defining photomicrographs.

Cite This Study

Bennett et al. (1976) studied this question.

synapsesocial.com/papers/69d72597236f4746d4563aebhttps://doi.org/10.1111/j.1365-2141.1976.tb03563.x
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