What question did this study set out to answer?

To evaluate the antinociceptive activity of myrcene isolated from lemon grass oil and characterize its underlying receptor mechanisms in mice.

December 1, 1990Journal of Pharmacy and Pharmacology

Effect of myrcene on nociception in mice

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Authors

VRV. S. N. RaoBrigham and Women's Hospital AMA. M. S. MenezesUniversidade Federal do Ceará GVG.S.B. VianaUniversidade Federal do Ceará

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Implication

Animal experiment demonstrates significant antinociception from lemongrass-derived myrcene in mice, suggesting an opioid- and alpha 2-adrenoceptor-mediated analgesic pathway.

Key Points

To evaluate the antinociceptive activity of myrcene isolated from lemon grass oil and characterize its underlying receptor mechanisms in mice.
Administered myrcene to mice intraperitoneally (10 and 20 mg kg-1) and subcutaneously (20 and 40 mg kg-1).
Assessed pain responses using a low-temperature (51.5 ± 0.5 °C) hot plate assay and an acetic acid-induced writhing test.
Tested mechanistic antagonism using the opioid antagonist naloxone (1 mg kg-1) and the alpha 2-adrenoceptor antagonist yohimbine (2 mg kg-1).
Myrcene produced significant inhibition of nociceptive responses in both the hot plate test and the acetic acid-induced writhing assay across all tested doses.
Pretreatment with naloxone or yohimbine significantly antagonized the antinociceptive effect of myrcene.
The antinociceptive action of myrcene appears to be mediated through alpha 2-adrenoceptor stimulation that triggers the release of endogenous opioids.

Cite This Study

Rao et al. (1990) studied this question.

synapsesocial.com/papers/69d72a2e236f4746d4563c0d https://doi.org/10.1111/j.2042-7158.1990.tb07046.x

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Implication

Animal experiment demonstrates significant antinociception from lemongrass-derived myrcene in mice, suggesting an opioid- and alpha 2-adrenoceptor-mediated analgesic pathway.

Effect of myrcene on nociception in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

Effect of myrcene on nociception in mice

Discussion

Member takes

Implication

Key Points

Cite This Study

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