February 2, 2017Open Access

Tissue Transglutaminase Modulates Vascular Stiffness and Function Through Crosslinking‐Dependent and Crosslinking‐Independent Functions

JSJochen SteppanNorthwestern University YBYehudit BergmanJohns Hopkins University KVKayla ViegasMacquarie University

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Abstract

TG2 modulates vascular function/tone by altering SMC contractility independent of its crosslinking function and contributes to vascular stiffness by regulating SMC proliferation and matrix remodeling.

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Steppan et al. (Thu,) studied this question.

synapsesocial.com/papers/69d72a80b6c880d6aaf50904 https://doi.org/https://doi.org/10.1161/jaha.116.004161

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