What question did this study set out to answer?

Develop and validate a gradient-weighted Markov Random Field model that integrates local gradient and global similarity approaches to parcellate the human cerebral cortex.

June 23, 2017Cerebral CortexOpen Access

Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI

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Develop and validate a gradient-weighted Markov Random Field model that integrates local gradient and global similarity approaches to parcellate the human cerebral cortex.
Formulated a gradient-weighted Markov Random Field (gwMRF) model combining local transitions in functional connectivity with global connectivity similarity.
Evaluated parcellations against four previously published schemes using resting-state fMRI and task-fMRI across diverse acquisition protocols in 1,489 participants.
Assessed alignment of parcel boundaries with known histological areas, visuotopic fMRI boundaries, and subareal functional organization.
gwMRF parcellations achieved greater functional homogeneity across task-fMRI and resting-state fMRI compared to four previously published parcellation schemes.
Parcel boundaries aligned closely with cortical areas defined by histology and visuotopic fMRI.
Certain parcels successfully captured subareal somatotopic and visuotopic computational units within established cortical areas.

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Implication

Computational neuroimaging study demonstrates improved cortical parcellation in 1489 participants, suggesting neurobiologically meaningful brain organization.

Cite This Study

Schaefer et al. (2017) studied this question.

synapsesocial.com/papers/69d72a92b815ed77c2bef17c https://doi.org/10.1093/cercor/bhx179

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Implication

Computational neuroimaging study demonstrates improved cortical parcellation in 1489 participants, suggesting neurobiologically meaningful brain organization.

Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI

Key Points

Discussion

Implication

Cite This Study

Local-Global Parcellation of the Human Cerebral Cortex from Intrinsic Functional Connectivity MRI

Key Points

Discussion

Implication

Cite This Study

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