The flagellar-specific Ca²⁺ channel CatSper is the predominant Ca²⁺ entry site in mammalian sperm. CatSper-mediated Ca²⁺ signaling affects nearly every event that regulates sperm to acquire fertilizing capability. In this review, we summarize some of the main findings from 20 years of CatSper research and highlight recent progress and prospects.
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Hwang et al. (2022) studied this question.
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