Quantitative comparison of cardiac ventricular myocyte electrophysiology and response to drugs in human and nonhuman species
Population
Detailed mathematical models for human, dog, and guinea pig ventricular action potentials (APs)
Comparison
Simulation of cell electrophysiology mechanisms… vs Comparison across species
Design
Preclinical
Authors
Discussion
Loading...
Member takes
Implication
Caution extrapolating I(Kr) blocker effects from animal models to humans; leaves open optimal preclinical species selection.
Structured PICO
P
Population
Detailed mathematical models for human, dog, and guinea pig ventricular action potentials (APs)
I
Intervention
Simulation of cell electrophysiology mechanisms and response to drugs (e.g., I(Kr) block, I(Ks) block, β-adrenergic stimulation)
C
Comparator
Comparison across species (human vs. dog vs. guinea pig)
O
Outcome
Action potential (AP) repolarization, rate-dependence mechanisms, and drug response (e.g., AP prolongation)surrogate
Significant species-dependent differences exist in cardiac ventricular myocyte electrophysiology and drug responses, indicating that extrapolating animal data to humans requires caution.
Cite This Study
O’Hara et al. (2011) studied this question.