Population
Human and canine ventricular myocytes
Comparison
Electrophysiological, pharmacological, and… vs Comparison between human and canine models
Design
Preclinical
Authors
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Species-specific Ito properties limit canine-to-human translation in electrophysiology; leaves open need for validated human-relevant models.
Significant phenotypic differences exist between human and canine ventricular Ito despite similar subunit protein expression, highlighting limitations of the canine model for human cardiac electrophysiology.
Akar et al. (2004) studied this question.
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