Why the study?
Does intracoronary adenoviral-mediated gene delivery of betaARKct delay the development of heart failure in a rabbit model of myocardial infarction?
Population
Rabbit model of heart failure induced by myocardial infarction
Design
Preclinical
Authors
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Hypothesis-generating in rabbit MI model; leaves open whether betaARKct gene therapy can prevent human heart failure.
Does intracoronary adenoviral-mediated gene delivery of betaARKct delay the development of heart failure in a rabbit model of myocardial infarction?
Inhibition of betaARK1 via gene delivery preserves myocardial beta-adrenergic receptor function and delays heart failure development after myocardial infarction in a rabbit model, challenging the notion that betaAR dampening is protective.
White et al. (2000) studied this question.
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