Demonstrates rapid induction of ventricular BNP gene expression in an experimental rat model of AMI, highlighting its role as an acutely responsive cardiac gene to ventricular overload.
May distinguish BNP from ANP responses in acute overload; leaves open human translation pending clinical studies.
These results demonstrate the rapid induction of ventricular BNP gene expression in rats with AMI compared with ANP and suggest that BNP gene expression in the ventricle is regulated distinctively from ANP gene expression against acute ventricular overload. They also suggest that the BNP gene can be one of the acutely responsive cardiac genes for the ventricular overload and suggest a possible pathophysiological role of BNP distinct from ANP in AMI.
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Hama et al. (1995) studied this question.
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