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Results of this cross-sectional study of 2 observational cohorts suggest that the p-tau abnormality as an early event in AD pathogenesis was associated with amyloid-β accumulation and highlights the need for careful interpretation of p-tau biomarkers in the context of the amyloid/tau/neurodegeneration, or A/T/(N), framework.
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Joseph Therriault
Montreal Neurological Institute and Hospital
Marie Vermeiren
Amsterdam Neuroscience
Stijn Servaes
Montreal Neurological Institute and Hospital
JAMA Neurology
University College London
University of Pittsburgh
McGill University
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Therriault et al. (Mon,) studied this question.
synapsesocial.com/papers/69d72f245dca7d66cbbef2f2 — DOI: https://doi.org/10.1001/jamaneurol.2022.4485