What question did this study set out to answer?

To investigate differences in the combined profile of gingival crevicular fluid microbiome and cytokines between healthy individuals and patients with periodontitis.

November 1, 2017Frontiers in MicrobiologyOpen Access

Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis

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Authors

JZJianye ZhouMinzu University of China YYYiqing YaoTianjin University of Traditional Chinese Medicine KJKangli JiaoNorthwest Minzu University

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Implication

Case-control study reveals disrupted correlation between oral microbiota and cytokine profiles in periodontitis, indicating immune-microbial dysbiosis drives disease.

Key Points

To investigate differences in the combined profile of gingival crevicular fluid microbiome and cytokines between healthy individuals and patients with periodontitis.
Sampled gingival crevicular fluid (GCF) from 16 periodontitis patients and 15 healthy controls in Jishi Shan (Gansu, China).
Characterized the bacterial microbiome via 454 pyrosequencing and quantified cytokine profiles using RayBio Quantibody Arrays.
Assessed microbial co-occurrence with Schoener's index and evaluated cytokine-microbiota concordance using Mantel and Procrustes tests.
C-reactive protein (CRP) was significantly higher in GCF of periodontitis patients (P < 0.05), while interleukin (IL)-8 was significantly higher in healthy controls (P < 0.01).
Mantel testing revealed significant concordance between cytokines and microbiota in the healthy group (Mantel statistic r = 0.36, P ≤ 0.05), but not in the periodontitis group (r = 0.013, P = 0.434).
MMP-9, osteoactivin, IL-8, and MIP-1a were significantly associated with bacterial composition across multiple taxonomic levels, while CRP was associated at the species level.

Cite This Study

Zhou et al. (2017) studied this question.

synapsesocial.com/papers/69d72f285dca7d66cbbef30d https://doi.org/10.3389/fmicb.2017.02144

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Implication

Case-control study reveals disrupted correlation between oral microbiota and cytokine profiles in periodontitis, indicating immune-microbial dysbiosis drives disease.

Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis

Discussion

Member takes

Implication

Key Points

Cite This Study

Relationship between Gingival Crevicular Fluid Microbiota and Cytokine Profile in Periodontal Host Homeostasis

Discussion

Member takes

Implication

Key Points

Cite This Study

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