Epothilones 1 (1 A: R = H; 1 B: R = Me) as promising, new microtubule-stabilizing natural products with taxol-like biological activity were isolated from myxo bacteria. A flexible and convergent total synthesis of epothilone A (1 A) and two formal total syntheses of epothilone B (1 B) for an easy and facile access to epothilones are reported.
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Schinzer et al. (1999) studied this question.