What question did this study set out to answer?

To review the cellular mechanisms, mitochondrial transport, and regulatory impacts of short- and medium-chain fatty acids on mammalian energy metabolism.

April 15, 2016SHILAP Revista de lepidopterologíaOpen Access

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

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To review the cellular mechanisms, mitochondrial transport, and regulatory impacts of short- and medium-chain fatty acids on mammalian energy metabolism.
Evaluated physiological processing of colonic-derived short-chain fatty acids and dietary medium-chain fatty acids across mammalian enterocytes, hepatocytes, and peripheral tissues.
Analyzed mitochondrial transport mechanisms, acyl-CoA activation, and impacts on glycolysis, gluconeogenesis, lipogenesis, and respiratory chain efficiency.
SCFAs and MCFAs undergo carnitine-independent cellular uptake and intramitochondrial activation to acyl-CoA thioesters with reduced reliance on fatty acid-binding proteins.
Both fatty acid classes modulate intermediary metabolism by generally suppressing glycolysis and promoting lipogenesis or gluconeogenesis.
SCFAs and MCFAs provide reducing equivalents to the mitochondrial respiratory chain without major lytic or protonophoric disruptions, though they moderately reduce oxidative ATP synthesis efficiency.

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Implication

Review reveals metabolic pathways of short- and medium-chain fatty acids in mammalian tissues, highlighting their carnitine-independent entry and regulation of mitochondrial ATP synthesis.

Cite This Study

Schönfeld et al. (2016) studied this question.

synapsesocial.com/papers/69d732683f2a6ac123b8a48a https://doi.org/10.1194/jlr.r067629

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Implication

Review reveals metabolic pathways of short- and medium-chain fatty acids in mammalian tissues, highlighting their carnitine-independent entry and regulation of mitochondrial ATP synthesis.

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

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Discussion

Implication

Cite This Study

Short- and medium-chain fatty acids in energy metabolism: the cellular perspective

Key Points

Discussion

Implication

Cite This Study

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