What question did this study set out to answer?

Summarize emerging global trends and molecular mechanisms driving the evolution and dissemination of multidrug-resistant bacterial pathogens.

August 12, 2009Journal of Antimicrobial ChemotherapyOpen Access

The changing epidemiology of resistance

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Authors

PHPeter M. HawkeyThe Edgbaston Hospital AJAnnie JonesWelsh Government

Discussion

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Implication

Review uncovers rapid global dissemination of multidrug-resistant bacterial strains across clinical and community settings, highlighting the urgent threat posed by mobile resistance genes.

Key Points

Summarize emerging global trends and molecular mechanisms driving the evolution and dissemination of multidrug-resistant bacterial pathogens.
Narrative review synthesizing molecular epidemiology and surveillance data regarding the global transmission of resistant bacterial clones.
Evaluated resistance determinants across major Gram-negative species (including Enterobacteriaceae) and Gram-positive pathogens (such as MRSA).
Horizontal gene transfer via conjugative plasmids accelerates the spread of broad-spectrum beta-lactamases like CTX-M and carbapenemases like KPC across diverse bacterial strains.
Co-carriage of plasmid-mediated resistance determinants, including AAC-6'-Ib-cr and qnr genes, facilitates the selection of high-level fluoroquinolone resistance driven by gyrA mutations.
Community-associated methicillin-resistant Staphylococcus aureus strains continue to proliferate globally, blurring the traditional clinical boundaries between hospital and community infections.

Cite This Study

Hawkey et al. (2009) studied this question.

synapsesocial.com/papers/69d7332ff07a12db70b8a452 https://doi.org/10.1093/jac/dkp256

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Implication

Review uncovers rapid global dissemination of multidrug-resistant bacterial strains across clinical and community settings, highlighting the urgent threat posed by mobile resistance genes.