Why the study?
It was unclear whether peak tricuspid regurgitation velocity >3.4 m/s remains reliable for predicting pulmonary hypertension under the new definition.
What is the optimal cut-off value of peak tricuspid regurgitation velocity to predict pulmonary hypertension according to the new definition (mPAP > 20 mmHg)?
What is the optimal cut-off value of peak tricuspid regurgitation velocity to predict pulmonary hypertension according to the new definition (mPAP > 20 mmHg)?
A peak tricuspid regurgitation velocity >2.8 m/s provides high sensitivity and good specificity for predicting pulmonary hypertension under the new definition of mPAP >20 mmHg.
Background: The 6th World Symposium on Pulmonary Hypertension proposed that precapillary pulmonary hypertension (PH) be defined as mean pulmonary arterial pressure (mPAP) >20 mmHg instead of mPAP ≥25 mmHg. Peak tricuspid regurgitation velocity (TRV) >3.4 m/s is widely used to predict PH, but it is unclear whether this value remains reliable for the new definition of PH. Methods and Results: We found that the optimal cut-off value of peak TRV for 511 PH patients was >2.8 m/s, with a sensitivity of 89.5%, specificity of 73.4%, and area under the curve of 0.89 (P<0.001). Conclusions: Based on the new definition of PH, TRV >2.8 m/s can be considered to indicate a high probability of PH.
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Sumimoto et al. (2020) studied this question.
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