What question did this study set out to answer?

To review the clinical indications, diagnostic utility, and histological scoring systems of liver biopsy across diverse chronic liver diseases.

February 22, 2022Clinical and Experimental MedicineOpen Access

Liver biopsy for assessment of chronic liver diseases: a synopsis

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Authors

ACAqib B. ChowdhuryKing's College London KMKosha J. MehtaKing's College London

Discussion

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Implication

Review demonstrates persistent gold-standard diagnostic and staging utility in chronic liver disease, highlighting its essential role alongside standardized histological scoring systems.

Key Points

To review the clinical indications, diagnostic utility, and histological scoring systems of liver biopsy across diverse chronic liver diseases.
Narrative synthesis of clinical evidence evaluating liver biopsy indications, procedural limitations, and pathological assessment protocols.
Comparative analysis of standardized histological grading and staging frameworks, including Ishak, METAVIR, Batts-Ludwig, NAS, and AHHS scores.
Liver biopsy remains the definitive diagnostic gold standard for direct morphological staging and grading despite the increased adoption of non-invasive tests.
Established scoring frameworks reliably quantify necroinflammatory activity and fibrosis progression across viral hepatitis, alcohol-related liver disease, NAFLD, and MAFLD.
Repeat biopsies offer valuable prognostic guidance and monitoring of treatment response, although clinical application must weigh sampling variability and procedural risks.

Cite This Study

Chowdhury et al. (2022) studied this question.

synapsesocial.com/papers/69d734d0ef4aa71f97f3071a https://doi.org/10.1007/s10238-022-00799-z

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Implication

Review demonstrates persistent gold-standard diagnostic and staging utility in chronic liver disease, highlighting its essential role alongside standardized histological scoring systems.