Inherited Mutations in Women With Ovarian Carcinoma

Barbara M. Norquist; Maria I. Harrell; Mark F. Brady; Tom Walsh; Ming K. Lee; Süleyman Gülsüner; Sarah S. Bernards; Silvia Casadei; Yi Qian; Robert A. Burger; John K. Chan; Susan A. Davidson; Robert S. Mannel; Paul DiSilvestro; Heather A. Lankes; Nilsa C. Ramirez; Mary‐Claire King; Elizabeth M. Swisher; Michael J. Birrer

doi:10.1001/jamaoncol.2015.5495

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Abstract

Of 1915 patients with OC, 347 (18%) carried pathogenic germline mutations in genes associated with OC risk. PALB2 and BARD1 are suspected OC genes and together with established OC genes (BRCA1, BRCA2, BRIP1, RAD51C, RAD51D, MSH2, MLH1, PMS2, and MSH6) bring the total number of genes suspected to cause hereditary OC to 11.

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Norquist et al. (2015) studied this question.

synapsesocial.com/papers/69d73537779571b57e48f4f1 https://doi.org/10.1001/jamaoncol.2015.5495

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Inherited Mutations in Women With Ovarian Carcinoma

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Inherited Mutations in Women With Ovarian Carcinoma

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